Multiple Hepatic Regulatory Variants at the GWAS Locus Associated with High-Density Lipoprotein Cholesterol

We examined the functional regulatory effects of candidate variants at the GALNT2 locus associated with high-density lipoprotein cholesterol (HDL-C). Fine-mapping and conditional analyses in the METSIM study identified a single locus harboring 25 noncoding variants (r2 > 0.7 with the lead GWAS variants) strongly associated with total cholesterol in medium-sized HDL (e.g., rs17315646, p = 3.5 × 10−12).

Source: The American Journal of Human Genetics - December 3, 2015 Category: Genetics & Stem Cells Authors: Tamara S. Roman, Amanda F. Marvelle, Marie P. Fogarty, Swarooparani Vadlamudi, Arlene J. Gonzalez, Martin L. Buchkovich, Jeroen R. Huyghe, Christian Fuchsberger, Anne U. Jackson, Ying Wu, Mete Civelek, Aldons J. Lusis, Kyle J. Gaulton, Praveen Se Tags: Article Source Type: research