Enhancing potency of siRNA for fusion genes [Applied Biological Sciences]

Canonical siRNA design algorithms have become remarkably effective at predicting favorable binding regions within a target mRNA, but in some cases (e.g., a fusion junction site) region choice is restricted. In these instances, alternative approaches are necessary to obtain a highly potent silencing molecule. Here we focus on strategies for...

Source: Proceedings of the National Academy of Sciences - December 1, 2015 Category: Science Authors: Gavrilov, K., Seo, Y.-E., Tietjen, G. T., Cui, J., Cheng, C. J., Saltzman, W. M. Tags: PNAS Plus Source Type: research