GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn’s disease

Conclusions This review article summarizes recent developments in the immunology of mucosal diseases and describes new aspects of the role of myeloid regulatory cells in IBD and the function of GM-CSF in maintaining the intestinal immune homeostasis in Crohn’s disease (CD). This review article highlights the exploration of stimulating in addition to suppressive therapies for patients with IBD and underpins that myeloid regulatory cells might become a promising novel cell-based therapeutic option.
Source: Molecular and Cellular Pediatrics - Category: Cytology Source Type: research