Immune suppressive mechanisms in the tumor microenvironment.
Immune suppressive mechanisms in the tumor microenvironment.
Curr Opin Immunol. 2015 Nov 20;39:1-6
Authors: Munn DH, Bronte V
Abstract
Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells. These often display inducible suppressive mechanisms that are triggered by the same anti-tumor inflammatory response that the immunotherapy intends to create. Therefore, a more comprehensive understanding of how the immunosuppressive milieu develops and persists is critical in order to harness the full power of immunotherapy of cancer.
PMID: 26609943 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Munn DH, Bronte V Tags: Curr Opin Immunol Source Type: research