Immunomodulation properties of multi-species fermented milks.

Immunomodulation properties of multi-species fermented milks. Food Microbiol. 2016 Feb;53(Pt A):60-69 Authors: Foligné B, Parayre S, Cheddani R, Famelart MH, Madec MN, Plé C, Breton J, Dewulf J, Jan G, Deutsch SM Abstract Dairy propionibacteria (PAB) are used as a ripening starter in combination with Lactic acid bacteria (LAB) for dairy products such as Swiss-type cheese. LAB and PAB have also been studied for their probiotic properties but little is still known about their individual and/or synergistic beneficial effects within dairy matrices. In the context of a rising incidence of Inflammatory Bowel Diseases, it has become crucial to evaluate the immunomodulatory potential of bacteria ingested in large numbers via dairy products. We therefore selected different strains and combinations of technological LAB and PAB. We determined their immunomodulatory potential by IL-10 and IL-12 induction, in human peripheral blood mononuclear cells, on either single or mixed cultures, grown on laboratory medium or directly in milk. Milk was fermented with selected anti-inflammatory strains of LAB or PAB/LAB mixed cultures and the resulting bacterial fractions were also evaluated for these properties, together with starter viability and optimum technological aspects. The most promising fermented milks were evaluated in the context of TNBS- or DSS-induced colitis in mice. The improvement in inflammatory parameters evidenced an alleviation of col...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research