The Selective Serotonin Reuptake Inhibitor Citalopram Decreases Human Immunodeficiency Virus Receptor and Coreceptor Expression in Immune Cells

This study investigated whether the selective serotonin reuptake inhibitor (SSRI) citalopram downregulates the expression of the human immunodeficiency virus (HIV) receptor cluster of differentiation 4 (CD4) and coreceptors chemokine receptor type 5 and chemokine-related receptor type 4 (CCR5 and CXCR4) on peripheral blood mononuclear cells (PBMC) and macrophages ex vivo as a potential mechanism of reducing susceptibility to HIV infection.

Source: Biological Psychiatry - November 7, 2015 Category: Psychiatry Authors: Jeffrey M. Greeson, David R. Gettes, Sergei Spitsin, Benoit Dubé, Tami D. Benton, Kevin G. Lynch, Steven D. Douglas, Dwight L. Evans Tags: Archival Report Source Type: research