Angiotensin-(1-7) Attenuates Kidney Injury Due to Obstructive Nephropathy in Rats

Conclusion Ang-(1–7) prevents obstructive nephropathy by suppressing renal apoptosis and fibrosis, possibly by regulating TGF-β1/Smad signaling and cell cycle arrest via suppression of AT1R expression. In addition, Ang-(1–7) increased and decreased ACE2 and TACE expression, respectively, which could potentially mediate a positive feedback mechanism via the Mas receptor.

Source: PLoS One - November 10, 2015 Category: Biomedical Science Authors: Chang Seong Kim et al. Source Type: research