Depression Common in Patients Awaiting Lung TransplantDepression Common in Patients Awaiting Lung Transplant
More than half of patients waiting for a lung transplant suffered from psychologic stress in a new study, which might be serious enough to affect transplant outcomes. Medscape Medical News
Increasing evidence suggests that greater depressive symptoms and reduced functional exercise capacity are associated with worse clinical outcomes following lung or heart transplantation. No studies, however, have prospectively assessed the associations between post-transplant depressive symptoms, actigraphy-assessed PA levels, and subsequent clinical outcomes in ambulatory transplant recipients.
Patients with a heart transplant who have depression have higher rates of graft failure and noncompliance; however, patients identified and treated early have outcomes similar to those without depression. The aim of this quality improvement project was to assess feasibility of implementing a universal depression screen —via the Patient Health Questionnaire (PHQ)-in a busy ambulatory heart transplant clinic.
Right ventricular dysfunction (RVD) in heart failure with reduced ejection fraction (HFrEF) drives morbidity and mortality. Clinical hemodynamic parameters such as elevated right atrial pressure to pulmonary capillary wedge pressure ratio (RAP/PCWP) and low pulmonary artery pulsatility index (PAPi) are widely used to identify patients with significant RVD. However, their correspondence to intrinsic RVD is unknown. We therefore tested whether RAP/PCWP or PAPi are associated with sarcomere and molecular dysfunction.
Although quality of life (QOL) has been widely reported in patients receiving LVADs, spiritual wellbeing among LVAD recipients is rarely included in these reports.
With an increased prevalence of anxiety and depression in advanced heart failure, left ventricular assist device (LVAD) implantation has recently been shown to mitigate some of these mental health issues by improved functional capacity and quality of life (QOL). There is mixed data available regarding LVAD strategy, so our aim was to compare emotional wellbeing between destination therapy (DT) and bridge to transplant (BTT) post LVAD based on existing QOL tools and preliminary data from a new tool, Quality of Life with a Left Ventricular Assist Device (QOLVAD).
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
ConclusionWith an experienced team, and the proper equipment, on-ECMO air transport of critical patients over thousands of kilometers is today safely feasible.
Conclusion: In this study we find significant difference in the level of anxiety and depression between CF patients who have not been transplanted and CF lung transplant recipients. Lung transplantation in CF patient significantly contributed to the improvement of the psychological condition and quality of life.