Loss of glycogen debranching enzyme AGL drives bladder tumor growth via induction of hyaluronic acid synthesis.

CONCLUSIONS: Our study establishes HAS2 mediated HA synthesis as a driver of growth of bladder cancer with low AGL and provides preclinical rationale for personalized targeting of HAS2/HA signaling in patients with low AGL expressing tumors.
PMID: 26490312 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 21, 2015 Category: Cancer & Oncology Authors: Guin S, Ru Y, Agarwal N, Ritterson Lew C, Owens C, Comi GP, Theodorescu D Tags: Clin Cancer Res Source Type: research