Mixed Ancestry and Disease Risk Transferability

Abstract Ancestry is the series of ancestors who form a line of descent or lineage back to an arbitrary founder or founding population. In recent years, integration of genome-wide genotype and sequence data from multiple populations worldwide has provided much insight into the identities and distributions of ancestral populations or clusters, thereby improving our understanding of historical migrations and current population structure at a sub-continental or regional level. Genetic ancestry, distinct from self-reported ancestry or ethnicity, serves both as a confounder in genetic association studies of genotypes and as a predictor in admixture mapping studies. This review focuses on the impact of genetic ancestry on transferability of genetic loci conferring disease risk.
Source: Current Genetic Medicine Reports - Category: Genetics & Stem Cells Source Type: research