CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis

Abstract Canine generalised demodicosis is recognised as a severe skin disease of dogs, and studies on CD4+ and CD8+ T cells in this disease condition have been limited. The aim of the present study was to record the CD4+ and CD8+ T cells in the peripheral blood of dogs affected with generalised demodicosis. Whole blood was collected from dogs with generalised demodicosis for estimation of CD4+ and CD8+ T cells by flow cytometry. The demodicosis-affected dogs had lower number of CD4+ T cells, increased CD8+ T cells, and reduced CD4+/CD8+ ratio compared to healthy controls. Present abnormalities in the study are related to the immunological response of the dogs to the mites in a disease process.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research