Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis.

In conclusion, HDL/S1P inhibits, while LDL/LPA stimulates TSP-1-induced VSMC chemotaxis. The HDL/S1P effect is mediated by the S1PR1-3 receptors. The LDL/LPA effects are mediated by the LPAR1 and LPAR2 receptors, but not LPAR3. Therefore, lipids have significant effects on TSP-1-induced VSMC chemotaxis. PMID: 26350564 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26350564?dopt=Abstract

Source: Molecular and Cellular Biochemistry - September 8, 2015 Category: Biochemistry Authors: Desai P, Stein JJ, Siddiqui SA, Maier KG, Gahtan V Tags: Mol Cell Biochem Source Type: research

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