Claudins and barrier dysfunction in intestinal inflammation: cause or consequence?
The intestinal epithelium forms a barrier between the body and the external environment facilitating the selective uptake of water, ions and nutrients while excluding bacteria, antigens and toxins. This raises the question whether breaches in this barrier can be a primary cause of intestinal inflammation or whether barrier loss is merely the inevitable consequence of inflammation causing epithelial damage, without barrier loss itself playing a pathogenic role. This question has puzzled investigators for decades and is of some importance, as the answer will determine whether restoring barrier loss is a plausible target for future therapy. Doubts about barrier loss playing an important causal role in inflammation have been fuelled by observations that some healthy individuals have an impaired barrier as measured by sugar absorption studies and in some circumstances barrier loss may actually be protective against intestinal inflammation.1 2 The intestinal barrier comprises a physical...
Publication date: Available online 6 April 2020Source: Clinica Chimica ActaAuthor(s): Julia L. Varghese, Angela W.S. Fung, Andre Mattman, Tien T.T. Quach, Deonne Thaddeus V. Gauiran, Mollie N. Carruthers, Luke Y.C. Chen
Publication date: Available online 6 April 2020Source: Clinica Chimica ActaAuthor(s): Niels Lech Pedersen, Mathias Mertz Petersen, Jon J. Ladd, Paul D. Lampe, Robert S. Bresalier, Gerard J. Davis, Christina Demuth, Sarah Ø. Jensen, Claus L. Andersen, Linnea Ferm, Ib Jarle Christensen, Hans J. Nielsen
Publication date: Available online 6 April 2020Source: Clinica Chimica ActaAuthor(s): Junxia Duan, Yue Zhao, Xiaohong Zhang, Han Jiang, Bibo Xie, Tie Zhao, Feijun Zhao
Conclusion: Severe acute pancreatitis during pregnancy leads to a high rate of fetal mortality.Gestational trimester, delayed diagnosis, HTG, MOF, gestational diabetes mellitus, and preeclampsia are predictors of fetal loss. Therefore, close monitoring is essential for pregnancies complicated with HTG, diabetes mellitus, and hypertension. PMID: 32249649 [PubMed - as supplied by publisher]
Authors: Pappas-Gogos G, Baltagiannis EG, Kyrochristos ID, Ziogas DE, Goussia A, Mitsis M, Roukos DH PMID: 32250157 [PubMed - as supplied by publisher]
Authors: Esteves JV, Yonamine CY, Machado UF PMID: 32250156 [PubMed - as supplied by publisher]
Authors: Nazemalhosseini-Mojarad E, Sanjabi F, Babini H PMID: 32250155 [PubMed - as supplied by publisher]
Authors: Thomsen CB, Jakobsen A PMID: 32250154 [PubMed - as supplied by publisher]
Conclusion: The mSHOX2/mPTGER4 assay showed some values with more limitations in lung cancer early detection. PMID: 32250153 [PubMed - as supplied by publisher]
CONCLUSIONS: The area-level risk of precarious employment matters for male workers' health independently from their job status, underscoring the importance of policy measures aimed to reduce the adverse impacts of precarious employment on workers' health. PMID: 32249269 [PubMed - as supplied by publisher]