Impaired cardiac and peripheral hemodynamic responses to inhaled β 2 -agonist in cystic fibrosis

Background:
Pulmonary system dysfunction is a hallmark of cystic fibrosis (CF) disease. In addition to impaired cystic fibrosis transmembrane conductance regulator protein, dysfunctional β
2
-adrenergic receptors (β
2
AR) contribute to low airway function in CF. Recent observations suggest CF may also be associated with impaired cardiac function that is demonstrated by attenuated cardiac output (Q), stroke volume (SV), and cardiac power (CP) at both rest and during exercise. However, β
2
AR regulation of cardiac and peripheral vascular tissue, in-vivo, is unknown in CF. We have previously demonstrated that the administration of an inhaled β-agonist increases SV and Q while also decreasing SVR in healthy individuals. Therefore, we aimed to assess cardiac and peripheral hemodynamic responses to the selective β
2
AR agonist albuterol in individuals with CF.
Methods:
18 CF and 30 control (CTL) subjects participated (ages 22 ± 2 versus 27 ± 2 and BSA = 1.7 ± 0.1 versus 1.8 ± 0.0 m
2
, both p 

Source: Respiratory Research - September 5, 2015 Category: Respiratory Medicine Authors: Erik Van ItersonStephen KarpenSarah BakerCourtney WheatleyWayne MorganEric Snyder Source Type: research