Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling

The link of chromatin remodeling to both neurodevelopment and cancer has recently been highlighted by the identification of mutations affecting BAF chromatin-remodeling components, such as ARID1B, in individuals with intellectual disability and cancer. However, the underlying molecular mechanism(s) remains unknown. Here, we show that ARID1B is a repressor of Wnt/β-catenin signaling. Through whole-transcriptome analysis, we find that in individuals with intellectual disability and ARID1B loss-of-function mutations, Wnt/β-catenin target genes are upregulated.

Source: The American Journal of Human Genetics - September 3, 2015 Category: Genetics & Stem Cells Authors: Georgia Vasileiou, Arif B. Ekici, Steffen Uebe, Christiane Zweier, Juliane Hoyer, Hartmut Engels, Jürgen Behrens, André Reis, Michel V. Hadjihannas Tags: Article Source Type: research