Differential effects of HRAS mutation on LTP-like activity induced by different protocols of repetitive transcranial magnetic stimulation

• Costello syndrome (CS) is due to a gain of function mutation in HRAS that is involved in LTP-like phenomena• PAS and iTBS induce a similar enhancement in brain excitability in healthy subjects.• PAS induces an extremely pronounced increase in motor cortex excitability in CS but till now no data about the effects of iTBS are available in these patients.• Unlike healthy subjects, PAS and iTBS induced differential effects on motor cortex excitability in CS.• HRAS differentially influences iTBS- and PAS-induced plasticity in humans.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 2, 2015 Category: Neurology Authors: Michele Dileone, Federico Ranieri, Lucia Florio, Fioravante Capone, Gabriella Musumeci, Chiara Leoni, Laura Mordillo-Mateos, Marco Tartaglia, Giuseppe Zampino, Vincenzo Di Lazzaro Source Type: research