Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research.

Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. Acta Derm Venereol. 2015 Aug 25; Authors: Melnik BC Abstract Increased expression of cathelicidin antimicrobial peptide (CAMP) is related to the pathogenesis of rosacea. CAMP plays a crucial role in antimicrobial defences, such as the killing of mycobacteria. CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPα) transcription factors. VDR-dependent CAMP expression is sufficient during the summer months in Nordic countries, but insufficient during Nordic winters, due to low ultraviolet (UV) levels. Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPα. C/EBPα is the downstream transcription factor of Toll-like receptor (TLR)-mediated innate immune reactions and endoplasmic reticulum (ER) stress responses. At the molecular level, all clinical trigger factors for rosacea can be regarded as ER stressors. A mutation-based upregulation of ER stress responsiveness in rosacea may thus explain patients' reduced threshold for ER stressors. It is notable that ER stress upregulates the potent lipid-mediator sphingosine-1-phosphate (S1P), which explains multiple pathological aberrations observed in rosacea skin. Enhanced ER stre...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

Related Links:

Calling it a “breakthrough,” the agency says it found vitamin E acetate in all 29 samples of lung fluid from patients with vaping-related lung injury.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Researchers have developed a preliminary guideline for the clinical management...Read more on AuntMinnie.comRelated Reading: CDC finds vitamin E acetate in 100% of vaping cases Vaping case study offers guidance for radiologists CDC names vaping-related illness, issues new guidance How to spot vaping-associated lung injury on imaging exams Vaping provokes lung disease in healthy individuals
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
VITAMIN D is a group of fat-soluble vitamins responsible for increasing intestinal absorption of calcium, magnesium and phosphate. It is a vitamin that is essential for good health and noticing a certain change in your hair could mean you are lacking the ‘sunshine vitamin’. What is it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AstraZeneca Plc said on Monday its experimental treatment significantly reduced disease activity in patients with autoimmune disorder lupus, in a late-stage study.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
It is now apparent that, as many of us figured out months ago, the use of vitamin E acetate oil as a thickening agent in THC vaping cartridges and perhaps other counterfeit or adulterated black market vaping products is causing the vaping-associated respiratory illness outbreak. Nevertheless, the CDC and at least one prominent anti-e-cigarette researcher have not yet given up in their attempt to pin the outbreak on traditional e-cigarettes which they apparently despise.The CDC continues to term this outbreak " E-cigarette, or vaping, product use associated lung injury. " This is an extremely odd name, especially ...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Roche today announced data from the phase II NOBILITY study, investigating the safety and efficacy of Gazyva ® (obinutuzumab) for adults with proliferative lupus nephritis.1 The study met the primary endpoint with Gazyva, in combination with standard of care (mycophenolate mofetil or mycophenolic acid and corticosteroids), demonstrating superiority compared to placebo plus standard of care.
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00757
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
Abstract Autoimmune diseases, such as rheumatoid arthritis, systematic lupus erythematosus and Sjögren's syndrome, are a group of diseases characterized by the activation of immune cells and excessive production of autoantibodies. Although the pathogenesis of these diseases is still not completely understood, studies have shown that multiple factors including genetics, environment and immune responses play important roles in the development and progression of the diseases. In China, there are great achievements in the mechanisms of autoimmune diseases during the last decades. These studies provide new insight...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Ben shared his 3-week experience living the Wheat Belly lifestyle after being diagnosed with celiac disease: “My family doctor diagnosed me with celiac and wheat allergies. These pictures were taken 3 weeks apart: prior to the diagnosis and three weeks later, a photo of me after following the Wheat Belly books that my doctor recommended I get. “I still feel like I eat like a king. I am just a lot more cautious about what I put into my body and I am seeing the results!” You can see that Ben’s face shows the changes we expect to see as inflammation recedes: reduced cheek and around-the-eyes edema, la...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories celiac gluten grains Inflammation Source Type: blogs
More News: Dermatology | Genetics | Lupus | Rosacea | Skin | Vitamin D Deficiency | Vitamins