Abstract 2732: The role of protein P in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third leading cause of cancer-related death worldwide. Although treatment options have improved in the past 30 years, 5-year survival rate remains below 20%. To improve the therapeutics of HCC, great efforts are needed in understanding the mechanisms underlying HCC. Protein P, plays an important role in the development of cancer. To clarify the role of P in the development of HCC, we investigated the expression level of P in HCC tissue chips. The results showed that P level is much higher in carcinoma than adjacent tissue, and the overall 5-year survival is much better in P low expression patients than in P high expression patients. P expression was also found to be increased in HCC cell lines, compared with the normal liver cell line. Further, the proliferation of HCC cell lines was suppressed significantly by siRNA-mediated P knockdown in both anchorage dependent and independent growth assays. These data suggested that P is a crucial factor in the development of HCC, which might therefore represent a novel therapeutic target for HCC.Citation Format: Hongyong Fu, Lianying Guo, Lin HUANG. The role of protein P in hepatocellular carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2732. doi:10.1158/1538-7445.AM2015-2732
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Carcinogenesis Source Type: research