Multimodal Neurophysiological Evaluation of Primary Progressive Multiple Sclerosis - An Increasingly Valid Biomarker, with Limits

Conclusions Multi-modal evoked potential batteries generally show moderate and useful correlation with clinical status as measured by the regulatory standard of EDSS (r=.65 vs. mEPS p<0.005) and MSFC (r=.39 vs. mEPS p<0.05). The graded qualitative mEPS scoring system displayed the strongest relationship although the influence of scoring system applied appeared reassuringly minimal. Non-association with cognitive impairment is an important limitation however.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research