E-127 intra-arterial thrombolysis for central retinal artery occlusion: a systematic review and meta-analysis

ConclusionIAT therapy for CRAO remains controversial. Pooled analysis of the retrospective studies supports IAT therapy whereas a single RCT does not support intervention. Other authors have suggested significant methodological concerns for the EAGLE study calling into question its conclusions that conflict with favorable studies of presumably lower levels of evidence.7 Additional study, potentially with stricter IAT time to treatment criteria may be warranted.ReferencesAhn SJ. Invest Ophthalmol Vis Sci. 2013;54(12):7746–55Aldrich EM. Stroke 2008;39:1746–50Arnold M J. Neurol Neurosurg Psychiatry 2005;76:196–199Schmidt DP. AJNR 2002;23:1301–7Weber J. Stroke 1998;29:2076–79Schumacher M. Ophthalmology 2010;117(7):1367–75Hayreh SS. Graefe Arch Ophthal. 2007;245:464–66DisclosuresP. Page: None. A. Cambon: None. R. James: 1; C; Microvention, Penumbra. 2; C; Pulsar, Covidien. 4; C; Remedy Pharmaceuticals.
Source: Journal of NeuroInterventional Surgery - Category: Neurosurgery Authors: Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research