Renal fibrosis: Kidney-specific deletion of Lkb1 perturbs intracellular metabolism and induces severe renal fibrosis

Nature Reviews Nephrology 11, 446 (2015). doi:10.1038/nrneph.2015.108 Author: Jessica K. Edwards Defects in metabolism and cellular polarity are thought to contribute to the development of chronic kidney disease (CKD). New research from Katalin Susztak and colleagues has identified liver kinase B1 (Lkb1) as an upstream regulator of fatty acid metabolism. Selective deletion of Lkb1
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research