Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms“

Publication date: Available online 26 July 2015 Source:Annals of Medicine and Surgery Author(s): Yonghua Bi, Hongshan Zhong, Xinwei Han, Ke Xu Aortic aneurysm is a silent but life-threatening disease, whose pathogenesis remains poorly understood. Aneurysm models have been induced in small animals to study its pathogenesis, Johnston WF et al. successfully induced a novel model of thoracic aortic aneurysms (TAA) by periadventitial application of elastase in mice.We comment on this model according to our experiment. We hypothesize that endogenous MMPs, especially MMP2, play a vital role in complex repair process of aneurysmal wall, which should be a key target in the investigation and treatment of aortic aneurysms.
Source: Annals of Medicine and Surgery - Category: Journals (General) Source Type: research