Impact of maraviroc-resistant mutation M434I in the C4 region of HIV-1 gp120 on sensitivity to antibody-mediated neutralization.

In this study, we examined the mutation most responsible for conferring enhanced neutralization sensitivity of the MVC resistant variant to several NMAbs and autologous plasma IgGs. The virus with the first resistant mutation, T297I, became sensitive to all NMAbs compared to the passage control virus. The neutralization sensitivity greatly increased following the second mutation M434I in the C4 region. The M434I mutation conferred the greatest neutralizing sensitivity among four MVC-resistant mutations, and the single M434I mutation was sufficient for the enhanced neutralization by NMAbs, autologous plasma IgGs and heterologous sera relative to the parental virus.
PMID: 26166507 [PubMed - as supplied by publisher]

Source: Japanese Journal of Infectious Diseases - July 10, 2015 Category: Infectious Diseases Authors: Boonchawalit S, Harada S, Shirai N, Gatanaga H, Oka S, Matsushita S, Yoshimura K Tags: Jpn J Infect Dis Source Type: research