Visible-light-induced C(sp3) –H bromination of 4-methylthiophene derivatives with HBr/H2O2

Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00547C, PaperWenbo Song, Ming Ma, Wenjing Zhang, Ranran Feng, Congcong Lu, Hong-Yu Zhang, Yuecheng Zhang, Jiquan Zhao A method to synthesize ethyl 4-(bromomethyl)thiophene-3-carboxylate derivatives utilizing HBr as the bromo source and H2O2 as the green oxidant under mild conditions is described. Preliminary synthetic applications and scale up experiments are also presented. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research