Cancers, Vol. 16, Pages 1777: & ldquo;Seeing Is Believing & rdquo;: Additive Utility of 68Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis

Cancers, Vol. 16, Pages 1777: “Seeing Is Believing”: Additive Utility of 68Ga-PSMA-11 PET/CT in Prostate Cancer Diagnosis Cancers doi: 10.3390/cancers16091777 Authors: Joel Chin Yu Guang Tan Alvin Lee Tze Kiat Ng Ruoyu Shi Charlene Yu Lin Tang Sue Ping Thang Jeffrey Kit Loong Tuan Christopher Wai Sam Cheng Kae Jack Tay Henry Sun Sien Ho Hung-Jen Wang Peter Ka-Fung Chiu Jeremy Yuen-Chun Teoh Winnie Wing-Chuen Lam Yan Mee Law John Shyi Peng Yuen Kenneth Chen Widespread adoption of mpMRI has led to a decrease in the number of patients requiring prostate biopsies. 68Ga-PSMA-11 PET/CT has demonstrated added benefits in identifying csPCa. Integrating the use of these imaging techniques may hold promise for predicting the presence of csPCa without invasive biopsy. A retrospective analysis of 42 consecutive patients who underwent mpMRI, 68Ga-PSMA-11 PET/CT, prostatic biopsy, and radical prostatectomy (RP) was carried out. A lesion-based model (n = 122) using prostatectomy histopathology as reference standard was used to analyze the accuracy of 68Ga-PSMA-11 PET/CT, mpMRI alone, and both in combination to identify ISUP-grade group ≥ 2 lesions. 68Ga-PSMA-11 PET/CT demonstrated greater specificity and positive predictive value (PPV), with values of 73.3% (vs. 40.0%) and 90.1% (vs. 82.2%), while the mpMRI Prostate Imaging Reporting and Data System (PI-RADS) 4–5 had better sensitivity and negative predic...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research