Combining trauma script exposure with tDCS to alleviate symptoms of Posttraumatic Stress Disorder: a two-arm randomized sham-controlled multicenter trial

Posttraumatic stress disorder (PTSD) affects 3.9% of the global population, with only half experiencing remission [1]. Exposure therapy for PTSD aims to act on identified dysregulated brain regions [2]. Certainly, functional alterations occur in key brain regions of the fear-processing network, including the amygdala (AMY) [3] and the ventromedial prefrontal cortex (vmPFC) [4], a top-down control region engaged in extinction. Furthermore, the left dorsolateral PFC (dlPFC), known for cognitive control and emotion appraisal, is implicated in top-down control of the vmPFC [4] and in intrusive traumatic memories [5].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 1, 2024 Category: Neurology Authors: No émie Eyraud, Pierre Poupin, Marc Legrand, Agnès Caille, Anne Sauvaget, Samuel Bulteau, Bénédicte Gohier, Ghina Harika-Germaneau, Dominique Drapier, Nematollah Jaafari, Olivier Bodic, Bruno Brizard, Valérie Gissot, Catherine Belzung, Jean-Baptiste Source Type: research