Iridium(III)-catalyzed photoredox cross-coupling of alkyl bromides with trialkyl amines: access to α-alkylated aldehydes

Chem Commun (Camb). 2024 Apr 30. doi: 10.1039/d4cc01043d. Online ahead of print.ABSTRACTA C(sp3)-C(sp3) cross coupling approach based on an iridium-photocatalytic radical process has been developed enabling the synthesis of various α-alkylated aldehydes from easily available/synthesized alkyl bromides and trialkyl amines under mild photocatalytic conditions. The synthesized aldehydes are also explored as a functional handle for various useful products such as carboxylic acid, alcohol and N-heterocycle synthesis.PMID:38686503 | DOI:10.1039/d4cc01043d

Source: Chemical Communications - April 30, 2024 Category: Chemistry Authors: Gaurav Shukla Malkeet Singh Saurabh Singh Maya Shankar Singh Source Type: research