Investigating Convergent Cellular Phenotypes in Schizophrenia-Associated Copy Number Variants

The two strongest genetic risk factors for schizophrenia (SCZ) are copy number variants (CNVs) at 3q29 and 22q11.2. In addition to risk for SCZ, there is substantial overlap in the phenotypic spectra associated with these two CNV syndromes. This phenotypic convergence strongly implies some degree of convergence at underlying biological levels. Currently there has been no report of a direct comparison of biological mechanisms associated with the 22q11 and 3q29 deletions.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research