438. Meta-Regression of Adjunctive Treatment Trials for Cognitive Deficits in Schizophrenia

A major challenge in schizophrenia drug development has been translating promising single-site findings to multicenter efficacy trials. Recently, a meta-analysis of studies in schizophrenia reported differential scaling of active and placebo treatment arms with increasing sample size, occurring in both monotherapy studies of antipsychotics and for adjunctive trials of negative symptoms. Here, we performed a similar analysis in treatment trials for cognitive impairment associated with schizophrenia (CIAS).
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research