Highly Sensitive SPR Biosensor for Malaria Detection Employing ZnO, Fe2O3, and Black Phosphorous

AbstractA highly sensitive surface plasmon resonance biosensor employing BK7 prism, Silver (Ag), zinc oxide (ZnO), ferromagnetic material (Fe2O3), and two-dimensional (2D) nanomaterial black phosphorous (BP) has been proposed. Thin layers of two different oxide layers sandwiched between Ag and BP in Kretschmann configuration. The angular interrogation method –based numerical simulation is applied for modelling of high performance SPR biosensor at a wavelength of 633 nm (visible region). Transfer matrix method and finite element methods have been used to obtain [performance parameters. This sensor can detect malaria at different stages and provides a large range of refractive index (RI) sensing from 1.369 to 1.409. The RI for malaria stages, including the ring, trophozoite, and schizont stages, are 1.396, 1.381, and 1.371 respectively, with corresponding angular sensitivities of 367 deg/RIU, 297 deg/RIU, and 269 deg/RIU. The sensor offers an ultrahigh angular sensitivity for malaria detection in ring stage. This research could pave the way for an important bio sample detection apparatus that allows for quick and precise in ring stage diagnosis.
Source: Plasmonics - Category: Biomedical Science Source Type: research