Cold denaturation of DNA origami nanostructures

Chem Commun (Camb). 2024 Apr 26. doi: 10.1039/d3cc05985e. Online ahead of print.ABSTRACTThe coupling of structural transitions to heat capacity changes leads to destabilization of macromolecules at both elevated and lowered temperatures. DNA origami not only exhibit this property but also provide a nanoscopic observable of cold denaturation processes by directing intramolecular strain to the most sensitive elements within their hierarchical architecture.PMID:38666465 | DOI:10.1039/d3cc05985e

Source: Chemical Communications - April 26, 2024 Category: Chemistry Authors: Daniel Dornbusch Marcel Hanke Emilia Tomm Charlotte Kielar Guido Grundmeier Adrian Keller Karim Fahmy Source Type: research