Macrophage niche imprinting as a determinant of macrophage identity and function

Cell Immunol. 2024 Apr 20;399-400:104825. doi: 10.1016/j.cellimm.2024.104825. Online ahead of print.ABSTRACTMacrophage niches are the anatomical locations within organs or tissues consisting of various cells, intercellular and extracellular matrix, transcription factors, and signaling molecules that interact to influence macrophage self-maintenance, phenotype, and behavior. The niche, besides physically supporting macrophages, imposes a tissue- and organ-specific identity on the residing and infiltrating monocytes and macrophages. In this review, we give examples of macrophage niches and the modes of communication between macrophages and surrounding cells. We also describe how macrophages, acting against their immune defensive nature, can create a hospitable niche for pathogens and cancer cells.PMID:38648700 | DOI:10.1016/j.cellimm.2024.104825
Source: Cellular Immunology - Category: Allergy & Immunology Authors: Source Type: research