In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition

In conclusion, B-01 ester compounds may be safe PK boosters with antedrug characteristics.PMID:38663182 | DOI:10.1016/j.dmpk.2024.101005

Source: Drug Metabolism and Pharmacokinetics - April 25, 2024 Category: Drugs & Pharmacology Authors: Makoto Kataoka Sae Takenaka Shota Fujii Takato Masada Keiko Minami Toshihide Takagi Masaaki Omote Kentaro Kawai Shinji Yamashita Source Type: research