Pharmacokinetics of tranexamic acid (TXA) delivered by expeditious routes in a swine model of polytrauma and hemorrhagic shock

CONCLUSIONS: In austere prehospital environments, an alternative to intravenous infusion of a life-saving medication is desired. Administration of TXA via all three methods reached the level needed to cause substantial inhibition of fibrinolysis within 10 minutes. The IV push method showed similar pharmacokinetics to IV infusion of TXA but can be delivered quickly without sacrificing an access site for 10 minutes.PMID:38634701 | DOI:10.1080/10903127.2024.2342025

Source: Prehospital Emergency Care - April 18, 2024 Category: Endocrinology Authors: Mallori Wilson Sean Stuart Brittany Lassiter Timothy Parker Clyde Martin Robert Healy Christopher Treager Eric Sulava Lorie Gower Pravina Fernandez Emily Friedrich Source Type: research