Lysosomal Peptide Self-Assembly To Control Cell Behavior

Chembiochem. 2024 Apr 25:e202400232. doi: 10.1002/cbic.202400232. Online ahead of print.ABSTRACTLysosomes are membrane-enclosed organelles that play key roles in degrading and recycling cellular debris, cellular signaling, and energy metabolism processes. Confinement of amphiphilic peptides in the lysosome to construct functional nanostructures through noncovalent interactions is an emerging approach to tune the homeostasis of lysosome. After briefly introducing the importance of lysosome and its functions, we discuss the advantages of lysosomal nanostructure formation for disease therapy. We next discuss the strategy for triggering the self-assembly of peptides in the lysosome, followed by a concise outlook of the future perspective about this emerging research direction.PMID:38660742 | DOI:10.1002/cbic.202400232
Source: Chembiochem - Category: Biochemistry Authors: Source Type: research