Emerging insights into transcriptional condensates

Experimental & Molecular Medicine, Published online: 25 April 2024; doi:10.1038/s12276-024-01228-9This review delves into the intricate realm of transcriptional regulation, a process that shapes the unique gene expression profiles of different cell types. It focuses on recent advances in elucidating the composition, property and role of transcriptional condensates, which are recently identified liquid-like entities composed of various proteins involved in transcription. Transcriptional condensate is the embodiment of ‘transcription factory’ concept, which contains high concentration of transcriptional proteins and exert control over neighboring genes. Using advanced imaging techniques, researchers found that these condensates dynamically interact with gene promoters to regulate transcription. They can also assemble in response to cellular signals, thus optimizing transcriptional efficiency and specificity. The review concludes that the dynamic relationship between these condensates and gene expression patterns is a promising area for future research and medical advancements.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research