Dihydroartemisinin is an inhibitor of trained immunity through Akt/mTOR/HIF1 α signaling pathway

In this study, we show that innate immune responses such as the production of extracellular traps, pro-inflammatory cytokines, and autophagy-related proteins were markedly augmented in trained BMDMs. Furthermore, heat-killed C. albicans priming promotes the activation of the AIM2 inflammasome, and AIM2-/- mice exhibit impaired memory response induced by heat-killed C. albicans. Therefore, we establish that the AIM2 inflammasome is involved in trained immunity and emerges as a promising therapeutic target for potentially deleterious effects. Dihydroartemisinin can inhibit the memory response induced by heat-killed C. albicans through modulation of mTOR signaling and the AIM2 inflammasome. The findings suggest that dihydroartemisinin can reduce the induction of trained immunity by heat-killed C. albicans in C57BL/6 mice. Dihydroartemisinin is one such therapeutic intervention that has the potential to treat of diseases characterized by excessive trained immunity.PMID:38636651 | DOI:10.1016/j.yexcr.2024.114052

Source: Experimental Cell Research - April 18, 2024 Category: Cytology Authors: Yu Gao Zhen-Zhen Liu Jia-Bao Zhang Cheng-Kai Zhou Jian-Gang Zhang Xiao-Qi Lin Qi Yin Wei Chen Yong-Jun Yang Source Type: research