New eremophilane-type sesquiterpenes from Synotis solidaginea

Fitoterapia. 2024 Apr 21:105970. doi: 10.1016/j.fitote.2024.105970. Online ahead of print.ABSTRACTEleven new highly oxygenated eremophilane-type sesquiterpenoids were isolated from the whole plant of Synotis solidaginea, including two pairs of C-8 S/R epimers. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configuration of 1 and 9 was confirmed by single-crystal X-ray crystallography using Cu Kα radiation. All the isolates were tested for the inhibition of LPS-stimulated NO production in macrophage-like mouse monocytic leukemia RAW264.7 cells. Compound 1 exhibited weak inhibitory effects with an IC50 of 71.2 μM.PMID:38653340 | DOI:10.1016/j.fitote.2024.105970

Source: Fitoterapia - April 23, 2024 Category: Biochemistry Authors: Xin-Yi Wei Hong-Bing Sun Rui-Ying Xi Fan Wu Yi-Lin Liu Zhuo-Lin Jin Da-Le Guo Bing Xia Fei Wang Yan Zhou Source Type: research