Stereoselective synthesis of gem-dihalopiperidines via the halo-aza-Prins cyclization reaction: access to piperidin-4-ones and pyridines

Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D4OB00338A, PaperSurjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera, Anil K. Saikia An efficient synthesis of 4,4-dihalopiperidines fromN-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide has been unveiled. 4,4-Dihalopiperidines have been transformed in one step into piperidin-4-ones, pyridines and enol ethers in reasonable yields. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research