Epigenetic dissection of human blood group genes reveals regulatory elements and detailed characteristics of KEL and four other loci

DISCUSSION: This combined bioinformatics and experimental approach revealed multiple candidate regulatory regions and predicted TF co-occupancy sites. The KEL promoter was characterized in detail, indicating that two adjacent GATA1 and KLF1 motifs are most crucial for transcription.PMID:38644556 | DOI:10.1111/trf.17840

Source: Transfusion - April 22, 2024 Category: Hematology Authors: Ping Chun Wu Eunike C McGowan Yan Quan Lee Sudip Ghosh Jenny Hansson Martin L Olsson Source Type: research