Marein, a novel natural product for restoring chemo-sensitivity to cancer cells through competitive inhibition of ABCG2 function

This study reveals a novel role and mechanism of marein in modulating drug resistance, and may have important implications in treatment of cancers that are resistant to chemotherapeutic drugs that belong to the substrates of ABCG2 transporters.PMID:38643907 | DOI:10.1016/j.bcp.2024.116219

Source: Biochemical Pharmacology - April 21, 2024 Category: Drugs & Pharmacology Authors: Yixuan Li Fanfan Guo Wenjing Wang FangLin Lv Lu Zhang Mingxian Zhu Shumin Yang Shunli Dong Mingxuan Zhou Zhenyun Li Zengyan Zhu Jin-Ming Yang Yi Zhang Source Type: research