Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models

In conclusion, tranilast improved visceral pain and colonic barrier by suppression of the NLRP3 inflammasome in IBS rat models. Tranilast may be useful for IBS treating.PMID:38643709 | DOI:10.1016/j.intimp.2024.112099

Source: International Immunopharmacology - April 21, 2024 Category: Allergy & Immunology Authors: Tsukasa Nozu Hideyuki Arie Saori Miyagishi Masatomo Ishioh Kaoru Takakusaki Toshikatsu Okumura Source Type: research