Beyond antiviral: role of IFN-I in brain development

Trends Immunol. 2024 Apr 20:S1471-4906(24)00073-5. doi: 10.1016/j.it.2024.04.004. Online ahead of print.ABSTRACTInterferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, Escoubas, Dorman, et al. recently identified a role for microglial type I interferon signaling in the clearance of unwanted neurons during mouse brain development.PMID:38644134 | DOI:10.1016/j.it.2024.04.004
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research