Rose Bengal Photodynamic Therapy (RB-PDT) Modulates the Inflammatory Response in LPS-Stimulated Human Corneal Fibroblasts By Influencing NF- κB and p38 MAPK Signaling Pathways

CONCLUSION: Rose bengal photodynamic therapy of lipopolysaccharide-stimulated human corneal fibroblasts can modify the inflammatory response by inducing interleukin-6 and interleukin-8 expression, and decreasing intercellular adhesion molecule-1 production. C-C motif chemokine ligand-4, interferon regulatory factor-3, and interferon α and β expressions are not affected by rose bengal photodynamic therapy in these cells. The underlying mechanisms may be associated with nuclear factor kappa B and p38 mitogen-activated protein kinase pathway activation.PMID:38646925 | DOI:10.1080/02713683.2024.2342600

Source: Cell Research - April 22, 2024 Category: Cytology Authors: Ning Chai Tanja Stachon Tim Berger Zhen Li Maryam Amini Shweta Suiwal Berthold Seitz Achim Langenbucher N óra Szentmáry Source Type: research