Cancers, Vol. 16, Pages 1600: Signaling by Type I Interferons in Immune Cells: Disease Consequences
Cancers, Vol. 16, Pages 1600: Signaling by Type I Interferons in Immune Cells: Disease Consequences
Cancers doi: 10.3390/cancers16081600
Authors:
Markella Zannikou
Eleanor N. Fish
Leonidas C. Platanias
This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.
Source: Cancers - Category: Cancer & Oncology Authors: Markella Zannikou Eleanor N. Fish Leonidas C. Platanias Tags: Review Source Type: research