Cancers, Vol. 16, Pages 1600: Signaling by Type I Interferons in Immune Cells: Disease Consequences

Cancers, Vol. 16, Pages 1600: Signaling by Type I Interferons in Immune Cells: Disease Consequences Cancers doi: 10.3390/cancers16081600 Authors: Markella Zannikou Eleanor N. Fish Leonidas C. Platanias This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research