Development of a defibrinated human blood hemolysis assay for rapid testing of hemolytic activity compared to computational prediction

CONCLUSION: We introduce a standardized, more accurate protocol for assessing hemolytic activity using defibrinated human red blood cells. This approach, facilitated by the increased commercial availability of de-identified human blood and defibrination methods, offers a robust tool for evaluating toxicity of emerging drug compounds, especially AMPs.PMID:38604530 | DOI:10.1016/j.jim.2024.113670
Source: Journal of Immunological Methods - Category: Allergy & Immunology Authors: Source Type: research