Unveiling the role of PD-L1 in vascular endothelial dysfunction: Insights into the mtros/NLRP3/caspase-1 mediated pyroptotic pathway

CONCLUSION: PD-L1-mediated activation of the inflammasome contributes significantly to the disruption of tight junction and induction of pyroptosis in ECs, where oxidative stress associated with mitochondrial dysfunction serves as a pivotal mechanism underpinning these effects.PMID:38631546 | DOI:10.1016/j.yexcr.2024.114047

Source: Experimental Cell Research - April 17, 2024 Category: Cytology Authors: Tianzhu Tao Ying Zhu Yue Shi Bingke Sun Yi Gu Shumin Xu Source Type: research