Approaches to optimize outcomes in transplant recipients

Hematology Am Soc Hematol Educ Program. 2023 Dec 8;2023(1):723-730. doi: 10.1182/hematology.2023000459.ABSTRACTCurative therapy with an allogeneic hematopoietic cell transplant (HCT) can now be offered to a wider patient population due to improvements in donor selection, transplant conditioning regimens, and supportive care measures. However, risk of transplant-related morbidity and mortality remains, and thus appropriate transplant candidate workup pre-HCT for risk stratification and a management plan after HCT is crucial for success of the procedure. These include understanding and identifying risk of underlying malignant disease relapse, graft-versus-host disease, and infectious complications a patient may be predisposed toward, irrespective of allogeneic donor type. Progress in these domains with new therapeutic paradigms allows for development of a treatment plan prior to HCT to mitigate these potential risks tailored to the patient's case. Herein, we present case studies to focus on factors that influence decision-making in HCT and the approaches and strategies used to optimize post-HCT outcomes based on the individual HCT recipient's clinical scenario to improve on these high-risk scenarios.PMID:38066935 | PMC:PMC10727018 | DOI:10.1182/hematology.2023000459
Source: Hematology ASH Education Program - Category: Hematology Authors: Source Type: research