The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPAR δ signaling pathway to prevent bone loss in ovariectomized rats and senile mice

In conclusion, these data strongly suggest that E0924G has the potential to prevent OVX-induced and age-related osteoporosis by dual regulation of bone formation and bone resorption through activation of the PPARδ signaling pathway.PMID:38636434 | DOI:10.1016/j.bioorg.2024.107364

Source: Bioorganic Chemistry - April 18, 2024 Category: Chemistry Authors: Yining Li Chao Liu Xiaowan Han Ren Sheng Li Bao Lijuan Lei Yexiang Wu Quanjie Li Yuyan Zhang Jing Zhang Weizhi Wang Yuhao Zhang Shunwang Li Chenyin Wang Xinwei Wei Jingrui Wang Zonggen Peng Yanni Xu Shuyi Si Source Type: research