Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer

Human Gene Therapy, Ahead of Print.

Source: Human Gene Therapy - March 28, 2024 Category: Genetics & Stem Cells Authors: Mark A. Brimble Christopher L. Morton Stephen M. Winston Isaiah L. Reeves Yunyu Spence Pei-Hsin Cheng Junfang Zhou Amit C. Nathwani Paul G. Thomas Aisha Souquette Andrew M. Davidoff Source Type: research